Abstract
Ten patients with intermittent claudication due to chronic obstructive arteriosclerotic disease (COAD) and ten control subjects without vascular disease were studied for the presence of circulating platelet aggregates. Patients exhibited significantly more platelet aggregates in their circulation than did the control subjects. The numbers of platelet aggregates were normalized after 1 1/2 years of therapy with 400 mg pentoxifylline (Trental) three times da1ly in the COAD patients. Higher single doses of pentoxifylline (800 and 1200 mg) given to the COAD patients inhibited ADP-induced platelet aggregation over a period of 6 hours post-dose.
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