Hemorheological parameters of anti-thrombotic agents. Naftidrofuryl and aspirin

Abstract

With a contactless photochemical process, endothelial cells can be damaged and thrombogenesis is initiated in vivo. In this paper, we communicate the use of hemorheological parameters to determine formation, growth and stability of the thrombi and the effect of two drugs on some of these parameters. Blood cell velocity is monitored from the onset of the endothelial damage until the vessel is occluded by the thrombus. The resulting time/velocity curves allow to discerne three different phases of thrombus growth, an additional parameter seems to be useful to assess thrombus stability in vivo. In our model, naftidrofuryl, an antagonist of serotonin₂ receptors, is shown to have potent anti thrombotic properties in clinically relevant dosages.