Abstract
The microporous membranes and ultrafilters used in cascade filtration membrane plasmapheresis were, in most, developed and qualified using blood of approximately normal composition. It is not a priori evident that these devices will perform satisfactorily when challenged with the high levels of protein concentration associated with hyperviscosity syndrome or paraproteinemia. We describe here the techniques for in-vivo assessment of the efficacy of the primary and secondary membrane plasma filters and illustrate their use via a technical case report of a patient with IgM paraproteinemia.
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