Association of cytotoxic T lymphocyte antigen-4 +49A/G polymorphism and cancer risk: An updated meta-analysis

Abstract

Background:

Associations between cytotoxic T lymphocyte antigen-4 (CTLA-4) +49A/G polymorphism and cancer risk are inconclusive. We performed this meta-analysis to derive a more precise estimation of the relationship.

Methods:

A comprehensive literature search was performed using electronic databases. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of association.

Results:

A total of 16,358 cases and 19,737 controls from 46 studies were included. Overall, significant association between CTLA-4 +49A/G polymorphism and cancer risk was observed in all genetic models (G vs. A: OR=0.88, 95%CI=0.83–0.93, ${\mathit{P}}_{\mathit{H}}$ =0.000; GA vs. AA: OR=0.87, 95%CI=0.79–0.97, ${\mathit{P}}_{\mathit{H}}$ =0.000; GG vs. AA: OR=0.75, 95%CI= 0.65–0.86, ${\mathit{P}}_{\mathit{H}}$ =0.000; GG vs. GA+AA: OR=0.84, 95%CI=0.79–0.91, ${\mathit{P}}_{\mathit{H}}$ =0.001; GG+GA vs. AA: OR=0.83, 95%CI=0.74–0.92, ${\mathit{P}}_{\mathit{H}}$ =0.000). Stratified analysis by cancer type revealed that the CTLA-4+49A/G polymorphism is associated with the decreased risk of cervical cancer, breast cancer, lung cancer, HCC. Further subgroup analysis by ethnicity indicated that there was a statistically decreased cancer risk in Asian population.

Conclusion:

This meta-analysis suggests that CTLA-4+49A/G polymorphism is associated with cancer risk, especially in Asian population.