Abstract
In this study, we have investigated interaction of sertraline hydrochloride as antidepressant drug in pharmaceutical formulation with eosin Y dye in aqueous buffered medium by optical absorption and fluorescence spectroscopic measurement. Strong hypochromic–bathochromic effects in absorbance and quenching in fluorescence were observed that showed strong binding of eosin Y to this drug via ion pair formation.
In order to explain the nature of eosin Y-drug interaction, the equilibrium constants and other thermodynamic functions for the process of eosin Y-sertraline ion pair formation were calculated using the UV-Visible absorption data. The results showed that formation of ion pair between eosin Y and sertraline was exothermic, characterized by large negative enthalpy and positive entropy changes.
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