The effectiveness of knee osteoarthritis treatment by arthroscopic microfracture technique in combination with autologous bone marrow stem cells transplantation

Abstract

OBJECTIVE:

We aimed to evaluate the efficacy of the treatment of knee osteoarthritis (OA) patients by using microfracture technique in combination with autologous bone marrow stem cell transplantation.

METHODS:

A clinical study was conducted between November 2011 and January 2015 and involved 46 patients (aged from 46 to 69) with primary knee OA grade II and III (according to Kellgren-Lawrence classification) at the Orthopedic Trauma Department, Vietnam-Germany Friendship Hospital. Patients were randomly assigned to receive knee arthroscopy and then bone-marrow stem cells from their pelvic bones via injection.

RESULTS:

The mean Visual Analogue Scale (VAS) score of present pain decreased from 5.68 before surgery to 1.7 24 months after surgery. The mean preoperative Knee Injury and Osteoarthritis Outcome Score (KOOS) was 36.34 ( $\pm$ 3.13), which increased to 74.62 ( $\pm$ 2.86) 24 months after surgery. On the MRI scans, the average Noyes score decreased from 12 ( $\pm$ 1.46) to 7 ( $\pm$ 1.50). Cartilage volume increased on average from 0.4512 ( $\pm$ 0.26) cm ${}^3$ to 0.5463 ( $\pm$ 0.29) cm ${}^3$ 12–24 months after surgery.

CONCLUSION:

Treatment of osteoarthritis by a combination of arthroscopic microfracture and transplantation of autologous bone-marrow stem cells was an invasive, safe and effective method which showed an improvement in the clinical symptoms (VAS score) and knee functions (KOOS points).