Effects of Egg Antibody to Components of Inflammatory Activation (Phospholipase a 2 and Toll Like Receptor 4) on the Response of Young Turkeys to Salmonella Typhimurium Challenge

Abstract

The effect of passive immunization against two components of the inflammatory response (Toll-like receptor 4 and phospholipase A₂) was examined in turkey poults receiving a challenge with Salmonella enterica serovar typhimurium (ST). The number of ST in the crop ingesta were not influenced by prior oral administration of egg antibody against Toll-like receptor 4 and phospholipase A₂. There was a marked effect of the passive immunization on the crop contents 48 hours following ST challenge. The crops of the ST challenged non-immune sera controls were distended and fluid filled while those of poults receiving egg antibody contained ingesta. The dry weights of the ingesta in the crop of the ST challenges non-immune egg immunoglobulin receiving birds were 510% those receiving egg antibody to Toll-like receptor 4 or phospholipase A₂. It is concluded that fluid accumulation in the crop of the young turkey following ST challenge may be a good model for bacterial enteric diseases where there is profuse watery diarrhoea. Moreover, passive immunization with antibody to Toll-like receptor 4 and phospholipase A₂ reduces the symptoms associated with salmonellosis and possibility other enteric diseases.