Abstract
An efficient, mild and Pd-catalysed C-2 arylation of Fmoc-L-tryptophan with diaryliodonium salts has been developed, giving easy access to C-2 arylated tryptophan derivatives. This protocol tolerates a variety of functional groups and proceeds smoothly in high yields without any additives. In addition, the chemoseletive C–H arylation with unsymmetrical salts is described.
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