Synthesis of new derivatives of 4-(4-methyl-5 H -pyrimido[4,5- b ][1,4]thiazin-2-yl)morpholine and 4-methyl-2-(piperidin-1-yl)-5 H -pyrimido[4,5- b ][1,4]thiazine
Free accessResearch articleFirst published online July, 2017
Synthesis of new derivatives of 4-(4-methyl-5 H -pyrimido[4,5- b ][1,4]thiazin-2-yl)morpholine and 4-methyl-2-(piperidin-1-yl)-5 H -pyrimido[4,5- b ][1,4]thiazine
Several derivatives of the novel 4-(4-methyl-5H-pyrimido[4,5-b][1,4]thiazin-2-yl)morpholine and 4-methyl-2-(piperidin-1-yl)-5H-pyrimido[4,5-b][1,4]thiazine ring systems have been synthesised through cyclocondensation of 5-amino-6-methylpyrimidine-4-thiols and the appropriate α-haloketone in glacial acetic acid under reflux.
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