Abstract
A series of novel 1-arylpyrazolo[3,4-d]pyrimidine derivatives, containing an amide moiety, was synthesised by condensation of different acids with 1-(2,4-dichlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine. This intermediate was prepared from 5-amino-1-(2,4-dichlorophenyl)-1H-pyrazole-4-carbonitrile by condensation with triethyl orthoformate and then cyclisation with ammonium hydroxide solution in tetrahydrofuran at room temperature. In addition, the molecular structure of a 1-arylpyrazolo[3,4-d]pyrimidine containing an amide moiety was determined by single crystal X-ray diffraction.
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