Abstract
A new series of 15-aryl-2,3,4,15-tetrahydrochromeno[2′,3′:4,5]pyrimido[6,1-b]quinazoline-1,9-diones was synthesised by the cyclisation of methyl anthranilate with ethyl N-(3-cyano-5-oxo-4-aryl-5,6,7,8-tetrahydro-4H-chromen-2-yl)formimidate derivatives, which were obtained by the reactions of 2-amino-5-oxo-4-aryl-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile derivatives and triethyl orthoformate. The structure of the 2,4-dichlorophenyl derivative was further determined by single crystal X-ray diffraction analysis.
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