Synthesis of Polysubstituted Pyrroles Derivatives by PPh 3 -Promoted Condensation Reaction between Ninhydrin,2-Amino Pyridine Derivatives and Acetylenes

Abstract

An efficient route for the synthesis of polysubstituted pyrrole derivatives through a three-component intermolecular Wittig reaction is described. This simple fragment assembly strategy uses mild conditions and affords a broad range of polysubstituted pyrroles in moderate to good yield from simple and readily available starting materials.