Four-Component Reaction of cyclohexyl isocyanide,acetylenic esters,carboxylic acids and pyrrole. Synthesis of dialkyl 2-alkanoyloxy (or benzoyloxy)-3-[cyclohexylimino(1 H -pyrrol-2-yl)methyl]succinates

Abstract

An improved four-component reaction of isocyanides is described. The reaction between cyclohexyl isocyanide, dialkyl acetylenedicarboxylates, carboxylic acids and pyrrole in dichloromethane at room temperature leads to 2-alkanoyloxy (or benzoyloxy)-3-[cyclohexylamino(1H-pyrrol-2-yl)methyl]succinates in good yields.