Abstract
The 4-arylated pyrimidin-2-yl tosylate derivatives, easily prepared from cheap commercial materials, reacted efficiently with propargyl alcohol/NaOBut to give the corresponding 4-arylated 2-propargyloxy-pyrimidine derivatives which, in a one-pot reaction catalysed by CuSO4·5H2O/sodium ascorbate, reacted with NaN3 and hexyl or benzyl bromide to give a series of 2-(1-hexyl- or 1-benzyl-1,2,3-triazol-4-yl)methoxy-pyrimidine derivatives in good yields.
Keywords
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