4-Aryl-Pyrimidin-2-Yl Tosylates as Efficient Reaction Partners: Application to the Synthesis of Pyrimidines Functionalised with Propargyloxy and 1,2,3-Triazolo Groups

Abstract

The 4-arylated pyrimidin-2-yl tosylate derivatives, easily prepared from cheap commercial materials, reacted efficiently with propargyl alcohol/NaOBut to give the corresponding 4-arylated 2-propargyloxy-pyrimidine derivatives which, in a one-pot reaction catalysed by CuSO₄·5H₂O/sodium ascorbate, reacted with NaN₃ and hexyl or benzyl bromide to give a series of 2-(1-hexyl- or 1-benzyl-1,2,3-triazol-4-yl)methoxy-pyrimidine derivatives in good yields.