Free accessResearch articleFirst published online 2014-12
Synthesis of Pyrrolo[2,3- b ]pyrazines Through Sonogashira Coupling Reaction of 5,6-dichloropyrazine-2,3-dicarbonitrile with Hydrazine,Phenylacetylene and Various Aldehydes
The Pd–Cu catalysed one-pot multicomponent reaction of 5,6-dichloropyrazine-2,3-dicarbonitrile with hydrazine, phenylacetylene, and a variety of aldehydes provides an efficient and direct method for the preparation of 5-(arylideneamino)-6-phenyl-5H-pyrrolo[2,3-b]pyrazine-2,3-dicarbonitriles.
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