Abstract
Sinomenine ether derivatives at C-4 (ring A) were reduced by LiAlH4 at the C-6 (ring C) to provide the corresponding hydroxyl derivatives with highly stereoselectivity. The desired products were obtained in excellent yields and fully characterised by 1H NMR, 13C NMR, MS spectra, elemental analysis and X-ray diffraction. The mild reaction conditions, readily available sinomenine ether derivatives, simple operation and high stereoselectivity make such a reaction highly attractive.
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