A green and highly efficient one-pot synthesis of 16 1,3,4,5-tetrasubstituted 1,2,3,6-tetrahydropyrimidines, four of which are new, using a three-component reaction involving an aniline, formaldehyde and a dialkyl acetylenedicarboxylate in aqueous media at room temperature catalysed by nano-MoO3 has been achieved.
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