Synthesis of Thiotetrazoles and Arylaminotetrazoles Using Rutile Tio 2 nanoparticles as a heterogeneous and reusable catalyst

Abstract

A novel method is described to prepare rutile TiO₂ nanoparticles which are reusable and efficient heterogeneous catalysts for the synthesis of thiotetrazoles and arylaminotetrazoles – compounds widely used in medicinal and coordination chemistry. This procedure has the advantages of good to excellent yields of products, elimination of homogeneous catalysts and toxic and explosive reagents, simple methodology, easy work up and the reusability of the heterogeneous catalyst.