Abstract
Several new 10-phenyl-[1,2,4]triazolo[1,5-b][2,7]naphthyridin-5(3H)-one derivatives were synthesised by condensation of 2,3-diamino-4-phenyl-2,7-naphthyridin-1(2H)-one with aldehydes and also with acid anhydrides. Their structures were confirmed by 1H NMR, 13C NMR, IR, mass spectra and elemental analysis. The key starting material 4-[a-cyano(phenyl)methyl]nicotinic acid was easily cyclised to give 3-amino-4-phenyl-1H-pyrano[3,4-c]pyridin-1-one under alkaline conditions, the structure of which was confirmed by X-ray crystallography following conversion to the corresponding N,N-dimethylformamidine derivative.
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References
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