Abstract
A series of novel (3E,4E)-1-aryl-3,4-bis[(benzo[d][1,3]dioxol-5-yl)methylidene]pyrrolidene-2,5-dione derivatives was synthesised and characterised by IR, 1H NMR and HRMS. Moreover, the molecular structure of (3E,4E)-3,4-bis [(benzo[d][1,3]dioxol-5-yl)methylene]-1-(4-ethoxyphenyl)pyrrolidine-2,5-dione was confirmed by the X-ray crystal structure determination.
References
1.
Salvati M.E.
,
Balog A.
,
Shan W.
, et al., Bioorg. Med. Chem. Lett. , 2008 , 18 , 1910 .
2.
Attar R.M.
,
Jure-Kunkel M.
,
Balog A.
, et al., Cancer Res. , 2009 , 69 , 6522 .
3.
Abdel-Aziz A.A.
,
El-Tahir K.E.
, and
Asiri Y.A.
, Eur. J. Med. Chem. , 2011 , 46 , 1648 .
4.
Paluchowska M.H.
,
Bugno R.
,
Duszynska B.
, et al., Bioorg. Med. Chem. , 2007 , 15 , 7116 .
5.
Iwai Y.
,
Takahashi H.
,
Hatakeyama D.
, et al., Bioorg. Med. Chem. , 2010 , 18 , 5379 .
6.
Murakamia Y.
,
Noguchia K.
,
Yamagoea S.
, et al., Antiviral Res. , 2009 , 83 , 112 .
7.
Chen K.X.
,
Nair L.
,
Vibulbhan B.
, et al., J. Med. Chem. , 2009 , 52 , 1370 .
8.
Bansode T.N.
,
Shelke J.V.
, and
Dongre V.G.
, Eur. J. Med. Chem. , 2009 , 44 , 5094 .
9.
Zhang Y.Y.
, and
Zhou C.H.
, Bioorg. Med. Chem. Lett. , 2011 , 21 , 4349 .
10.
Xie L.J.
,
Cui J.N.
,
Qian X.H.
, et al., Bioorg. Med. Chem. , 2011 , 19 , 961 .
11.
Ferri N.
,
Radice T.
,
Antonino M.
, et al., Bioorg. Med. Chem. , 2011 , 19 , 5291 .
12.
Settimo Da
,
Primofiore G.
,
Da Settimo F.
Eur. J. Med. Chem. , 1996 , 31 , 49 .
13.
Mehta N.B.
,
Phillips A.P.
,
Lui F.F.
, and
Brooks R.E.
, J. Org. Chem. 1960 , 25 , 1012 .
14.
Walker M.A.
, J. Org. Chem. , 1995 , 60 , 5352 .
15.
Bose A.K.
,
Manhas M.S.
,
Ghush M.
, et al., Heterocycles , 1990 , 30 , 741 .
16.
Dong W.L.
,
Yao W.J.
,
Wei F.
, and
Zhao B.X.
, Acta Crystallogr., Sect. E , 2007 , 63 , o2776 .
17.
Hart R.J.
,
Heller H.G.
,
Megit R.M.
, and
Szewczyk M.
, J. Chem. Soc., Perkin Trans. 1 , 1975 , 2227 .
18.
Crescente O.
,
Heller H.G.
, and
Oliver S.
, J. Chem. Soc., Perkin Trans. 1 , 1979 , 150 .
19.
Chakraborty D.P.
,
Sleigh T.
,
Stevenson R.
, et al., J. Org. Chem. , 1966 , 31 , 3342 .
20.
Cohen M.D.
,
Kaufmann H.W.
,
Sinnreich D.
, and
Schmidt G.M.
, J. Chem. Soc. (B) , 1970 , 1035 .
21.
Jiaang W.T.
,
Wang C.L.
,
Tseng A.
, and
Chen S.T.
, Heterocycles , 2000 , 53 , 1569 .
22.
Brunow G.
, and
Tylli H.
, Acta Chem. Scand. , 1968 , 22 , 690 .
23.
Davidse P.A.
, and
Dillen J.L.M.
, Acta Crystallogr., Sect. C , 1990 , 46 , 1040 .
24.
Cremer D.
, and
Pople J.A.
, J. Am. Chem. Soc. , 1975 , 97 , 1354 .
25.
Sheldrick G.M.
, SHELX-97, Program for the Refinement of Crystal Structures , University of Gottingen : Gottingen , 1997 .