Abstract
Cyano-N-(2-oxo-1,2-dihydroindol-3-ylidene)acetohydrazide was prepared by condensation of isatin with cyanoaceto-hydrazide in refluxing 1,4-dioxane. Subsequent reaction with a variety of electrophilic and nucleophilic reagents afforded novel heterocyclic compounds and spirooxoindoles. The IR, 1H NMR and mass spectra of all the synthesised compounds are discussed.
References
1.
Zhou
L.
,
Liu
Y.
,
Zhang
W.
,
Wei
P.
,
Huang
C.
,
Pei
J.
,
Yuan
Y.
, and
Lai
L.
, J. Med. Chem. , 2006 , 49 , 3440 .
2.
Matheus
M.E.
,
Violante
F.A.
,
Garden
S.J.
,
Pinto
A.C.
, and
Fernandes
P.D.
, Eur. J. Pharmacol. , 2007 , 556 , 200 .
3.
Yogeeswari
P.
,
Sriram
D.
,
Thirumurugan
R.
,
Raghavendran
J.V.
,
Sudhan
K.
,
Pavana
R.K.
, and
Stables
J.
, J. Med. Chem. , 2005 , 48 , 6202 .
4.
Ine
K.L.
,
Locke
J.M.
,
Ranson
M.
,
Pyne
S.G.
, and
Bremner
J.B.
, J. Med. Chem. , 2007 , 50 , 5109 .
5.
Da Silva
J.M.
,
Garden
S.J.
, and
Pinto
A.C.
, J. Braz. Chem. Soc. , 2001 , 12 , 273 .
6.
Glover
V.
,
Halket
J.M.
, and
Watkins
P.J.
, J. Neurochem. , 1988 , 51 , 656 .
7.
Bhattacharya
S.K.
,
Glover
V.
, and
McIntyre
I.
, Neurosci. Lett. , 1982 , 92 , 218 .
8.
Chohan
Z.H.
,
Pervez
H.
, and
Rauf
A.
, J. Enz. Inhib. Med. Chem. , 2004 , 19 , 417 .
9.
Pandeya
S.N.
,
Smitha
S.
,
Jyoti
M.
, and
Sridhar
S.K.
, Acta Pharm. , 2005 , 55 , 27 .
10.
Bondock
S.
,
Tarhoni
A.E.G.
, and
Fadda
A.A.
, Arkivoc , 2006 , ix , 113 .
11.
Marcos
A.P.M.
,
Dayse
N.M.
,
Clarissa
P.F.
,
Kelvis
L.N.Z.
, and
Helio
G.B.
, J. Braz. Chem. Soc. , 2008 , 19 , 1361 .
12.
Mahmoud
M.R.
,
E1-Ziaty
A.K.
,
Ismail
M.F.
, and
Shiba
S.A.
, Eur. J. Chem. , 2011 , 2 , 347 .
13.
Mahmoud
M.R.
,
El-Shahawi
M.M.
, and
Abu El-Azm
F.S.M.
, Eur. J. Chem. , 2011 , 2 , 404 .
14.
Mahmoud
M.R.
,
Madkour
H.M.F.
,
El-Bordany
E.A.A.
, and
Soliman
S.A.
, Eur. J. Chem. , 2011 , 2 , 475 .
15.
Mahmoud
M.R.
,
El-Shahawi
M.M.
,
Abu El-Azm
F.S.M.
, and
Farahat
S.E.
, Am. J. Org. Chem. , 2011 , 1 , 14 .
16.
Mahmoud
M.R.
,
Abou-Elmagd
W.S.I.
,
Derbala
H.A.
, and
Hekal
M.H.
, Chinese J. Chem. , 2011 , 29 , 1446 .
17.
Mahmoud
M.R.
,
Abou-Elmagd
W.S.I.
,
Abd El-Wahab
S.S.
, and
Soliman
S.A.
, J. Chem. Res. , 2012 , 66 .
18.
Mahmoud
M.R.
,
Abou-Elmagd
W.S.I.
,
Derbala
H.A.
, and
Hekal
M.H.
, J. Chem. Res. , 2012 , 75 .
19.
Mahmoud
M.R.
,
Madkour
H.M.F.
,
Habashy
M.M.
, and
El-Shwaf
A.M.
, Am. J. Org. Chem. , 2012 , 2 , 39 .
20.
Mahmoud
M.R.
,
E1-Ziaty
A.K.
, and
Hussein
A.M.
, World Appl. Sci. J. , 2012 , 17 , 101 .
21.
Mohammed
Y.S.
,
Regaila
H.A.A.
,
Gohar
A.K.M.
,
Abdel-Latif
F.F.
, and
Ahmed
E. Kh.
, Egypt. J. Pharm. Sci. , 1988 , 29 , 419 . [Chem. Abstr. , 1989, 110 , 231374].