Iodobenzene Diacetate (PIDA)/Zn(II)-Mediated Oxidation and Cleavage of C–C Bond: Formation of Substituted N-aryl Carbamoyl Methyl Diacetates and Derivatives from 3-oxo-butanamides
Free accessResearch articleFirst published online October, 2012
Iodobenzene Diacetate (PIDA)/Zn(II)-Mediated Oxidation and Cleavage of C–C Bond: Formation of Substituted N-aryl Carbamoyl Methyl Diacetates and Derivatives from 3-oxo-butanamides
Various substituted N-aryl carbamoyl methyl diacetates have been synthesized from N-aryl-3-oxobutanamides via a diacetoxylation mediated by the combination of iodobenzene diacetate (PIDA)/Zn(OAc)2. This provides a new convenient method to form C–O bonds and cleave C–C bonds. Ten examples were obtained from easily available materials in good to excellent yields.
