Abstract
A new lycopodine alkaloid, 6α, 11α-dihydroxylycopodine, and three known compounds L20, lycoposerramine K, and huperzine A were isolated from the stems of Huperzia serrata. The structure of the new alkaloid was established by spectroscopic methods, especially two-dimensional NMR techniques.
Keywords
References
1.
Kobayashi J.
, and
Morita H.
, The alkaloids , ed.
Cordell G.A.
, Academic Press , New York , 2005 , Vol. 61 , pp. 1 –57 .
2.
Morita H.
,
Hirasawa Y.
, and
Kobayashi J.
, J. Nat. Prod. , 2005 , 68 , 1809 .
3.
Maclean D.B.
, The alkaloids , ed.
Brossi A.
, Academic Press , New York , 1985 , Vol. 26 , pp. 241 –298 .
4.
Kozikowski A.P.
, and
Tückmantel W.
, Acc. Chem. Res. , 1999 , 32 , 641 .
5.
Liu J.S.
,
Zhu Y.L.
,
Yu C. M.
,
Zhou Y.Z.
,
Han Y.Y.
,
Wu F.W.
, and
Qi B.F.
, Can. J. Chem. , 1986 , 64 , 837 .
6.
Bai D.L.
,
Tang X.C.
, and
He X.C.
, Curr. Med. Chem. , 2000 , 7 , 355 .
7.
Wong D.M.
,
Greenblatt H.M.
,
Dvir H.
,
Carlier P.R.
,
Han Y.F.
,
Pang Y.P.
,
Silman I.
, and
Sussman J.L.
, J. Am. Chem. Soc. , 2003 , 125 , 363 .
8.
Tan C.H.
, and
Zhu D.Y.
, Helv. Chim. Acta , 2004 , 87 , 1963 .
9.
Zhu D.Y.
, and
Tan C.H.
, The lycopodium alkaloids , ed.
Wang F. P.
, Chemical Industry Press , Beijing , 2007 . Vol. 6 , pp. 92 –117 .
10.
Takayama H.
,
Katakawa K.
,
Kitajima M.
,
Yamaguchi K.
, and
Aimi N.
, Chem. Pharm. Bull. , 2003 , 51 , 1163 .
11.
Koshiba T.
,
Yokoshima S.
, and
Fukuyama T.
, Org. Lett. , 2009 , 11 , 5354 .