Abstract
The one-pot three-component reaction of 1,3-disubstituted barbituric acid derivatives, 3-formylchromones and alkyl isocyanides proceed smoothly at room temperature to give the corresponding chromone-containing furopyrimidines derivatives in good yields within 10 minutes in DMF. This three-component reaction represents a facile and efficient route to the furo[2,3-d]pyrimidine derivatives, which have become synthetic targets for many organic and medicinal chemists. In the course of the creation of a fused furopyrimidine ring, three bonds (C=C, C–C and C–O bonds) are newly formed.
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