Abstract
A simple and efficient method has been developed for stereoselective one-pot synthesis of (E)-3-(4-arylpiperazin-1-yl)-1-arylprop-2-en-1-ones by condensation of aryl ketones with arylpiperazines and N, N-dimethylformamide dimethyl acetal in acetic acid with 54–69% yields. Compared with reported methods, this one-step procedure appears to be a useful approach to prepare (E)-β-enaminoketones with good stereoselectivity, simple operation and moderate yields.
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