Sage Journals: Discover world-class research

Abstract

The kinetics and mechanism of formation of [Fe(CN)₅INH]^3- by a ligand substitution reaction between aquapentacyanoferrate(II) ion and isoniazid, (pyridine-4-carboxylic acid hydrazide) (INH) have been investigated spectrophotometrically in acidic media at 435 nm (Λ_max of product), under pseudo-first order conditions, using excess of INH over [Fe(CN)₅H₂O]^3-. The reaction was studied as a function of [Fe(CN)₅H₂O^3-], [INH], pH, ionic strength and temperature, by varying only one of these variables while other variables were held constant. The reaction exhibited first-order kinetics in [INH] while it was independent of [Fe(CN)₅H₂O^3-] in the chosen concentration range. The effect of temperature on the reaction rate yielded the activation parameters. The most plausible mechanism consistent with the experimental results has been proposed.

Keywords

ligand substitution aquapentacyanoferrate(II)isoniazid spectrophotometry

References

Blandamer

M.J.

, Burgess

, and Haines

R.I.

(1976) J. Chem. Soc., Dalton Trans., 1293.

Sullivan

T.R.

, Stranks

D.R.

, Burgess

, and Haines

R.I.

(1977) J. Chem. Soc. Dalton Trans., 1460.

Bradic

, Pribanic

, and Asperger

(1975) J. Chem. Soc., Dalton Trans., 353.

Katz

N.E.

, Aymonino

P.J.

, Blesa

M.A.

, and Olabe

J.A.

(1978) Inorg. Chem., 17, 556.

Blandamer

M.J.

, Burgess

, Morcom

K.W.

, and Sherry

(1989) Trans. Met. Chem., 8, 354.

Pedrosa

G.C.

, Salas

J.A.

, Katz

, and Katz

N.E.

(1983) J. Coord. Chem., 12, 145.

Macartney

D.H.

(1988) Rev. Inorg. Chem., 9, 101.

Bal Reddy

, and van Eldik

(1991) Inorg. Chem., 30, 96.

Alshehri

, and Burgess

(1991) Inorg. Chim. Acta, 181, 53.

10.

Toma

H.E.

, and Malin

J.M.

(1973) Inorg. Chem., 12, 2080.

11.

Brauer

(1965) In: Handbook of preparative inorganic chemistry, 2nd edn, p. 1511. Academic Press, New York.

12.

West

R.C.

(1969) C.R.C. handbook of chemistry and physics, vol. 49, p. D-79, Chemical Rubber Co., Ohio.

13.

Garafalo

A.R.

, and Davis

(1976) Inorg. Chem., 15, 1787–1790.

14.

Abu-Gharib

E.A.

, Ben

A.R.

, Blandamer

M.J.

, and Burgess

(1987) Trans. Met. Chem., 12. 371–378.

15.

Moya

M.L.

, and Burgess

(1991) J. Chem. Soc. Faraday Trans., 87, 2573.

16.

Taube

M.L.

(1968) Inorg. Chem., 7, 1260–1264.

Kinetics and Mechanism of Formation of [Fe(Cn) 5 Inh] 3- by Ligand Substitution in Acidic Media (Inh = Isoniazid)

Abstract

Keywords

References