One novel sesquiterpenoid guaiane glucoside, hedyosmum F, and three known sesquiterpenoids, hedyosmum D–E and 7, 10-epoxy-hedyosminolide were isolated from the aerial of Hedyosmum orientale. The structure of hedyosmum F was established on the basis of spectroscopic data, including IR, HR-ESI-MS, 1D and 2D NMR spectroscopy.
