Starting from 2-benzoylbenzoic acid (1) and prototype hydrazine itself or some of its simple congeners produce phthalazin-1(2H)-one derivatives 2a–d. Reactions of 2 with P2S5 or POCl3 gave their thione derivatives 3a–c or the chloro derivative 4 respectively. Further reactions of phthalazines 3 and 4 with hydrazine derivatives afforded their hydrazinyl derivatives 5a–d. Compounds 5a and 5d were used as a precursor to triazolo 6 and pyrazolyl phthalazines 7. The antimicrobial activities of some of the prepared phthalazines were tested.
CarlingR.W., MooreK. W., StreetL. J., WildD., IstedC., LeesonP. D., ThomasS., O'ConnerD., McKernanR. M., QuirkK., CookS. M., AtackJ. R., WaftordK. A., ThompsonS. A., DawsonG. R., FerrisP., and CastroJ. L., J. Med. Chem., 2004, 47, 1807.
4.
GrassoS., DeSarroG., MicaleN., ZappalaM., PuiaG., BaraldiM., and DemicheliC., J. Med. Chem., 2000, 43, 2851
