An efficient and convenient synthesis of heteryl (E)-styryl sulfones is described. Reaction of an 3-(2-bromoacetyl)coumarin with sodium (E)-styrenesulfinates yields the corresponding styryl sulfones promoted by polyethylene glycol (PEG-400) as an efficient reaction medium at room temperature
ReddyM.V.R., ReddyM. M., StephenC. C., VenkatP. R., NabisaM. I., KimberlyR. A., AnthonyK. D., and ReddyE. P., J. Med. Chem., 2008, 51, 86.
2.
ReddyE.P., and ReddyM. V. R., U.S. Patent 6548553, 2003.
3.
ReddyE.P., and ReddyM. V. R., European Patent, 1027330, 2004.
4.
ReddyE.P., and ReddyM. V. R., U.S. Patent 6359013, 2002.
5.
ReddyE.P., and ReddyM. V. R., U.S. Patent, 6201154, 2001.
6.
ReddyM.V. R., ReddyM. M., VenkatR. P., PadmavathiV., RengasamyB., StanleyC. B., and ReddyE. P., J Bioorg. Medic. Chem., 2005, 13, 1715.
7.
ReddyA.K., LohrayB. B., BhushanV., ReddyA. S., MamidiN. V. S. R., ReddyP. P., SaibabaV., ReddyN. J., SuryaprakashA., MisraP., VikramadithanR. K., and RajagopalanR., J. Med. Chem., 1999, 42, 3265.
8.
ReddyD.B., ChandrasekharN., PadmavathiV., and PadmajaA., Tetrahedron, 1997, 53, 17351.
9.
ReddyM.V. R., ReddyS., ReddyD. B., and PadmavathiV., Syn. Commm., 1989, 19, 1101.
10.
ReddyM.V. R., and ReddyS., Acta Chim. Hung., 1984, 115, 269.
11.
ReddyD.B., ReddyN. S., ReddyS., ReddyM. V. R., and BalasubramanyamS., Org. Prep. Proc. Int., 1988, 20, 205.