Synthesis of acyclo C -Nucleosides of H 1 -antihistaminic 4-substituted [1,2,4]triazolo[4,3- a ]quinazolin-5(4 H )-ones

Abstract

Two series of aldose N-(3-substituted-4-oxo-3,4-dihydroquinazolin-2-yl)hydrazones were prepared by the reaction of each of the aldoses with the appropriate 2-hydrazino-3-substituted-quinazolin-4(3H)-ones. Oxidative cyclisation of these aldose hydrazones with ferric chloride in ethanol yielded the title acyclo C-nucleosides.