A simple, efficient and environmentally friendly procedure for one-pot solid-phase synthesis of 2-oxazolidinones in moderate to good yields by reaction of polystyrene-supported 2-hydroxyalkyl selenide with benzoyl isocyanate and subsequent oxidation/cyclisation-hydrolysis using a selenium traceless linker strategy is described.
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Some molecules containing the oxazolidin-2-one moiety have shown interesting pharmaceutical activity. For recent leading references, see: (a) AhmedS., AdatS., MurrellsA., and OwenC.P., Biochem. Biophys. Res. Commun., 2002, 294, 380; (b) A. Mai, M. Artico, M. Esposito, G. Sbardella, S. Massa, O. Befani, P. Turini, V. Giovannini and B. Mondovi, J. Med. Chem., 2002, 45, 1180; (c) M. Seki and K. Mori, Eur. J. Org. Chem., 1999, 64, 2965.
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