(S)- and (R)-2-[3-cyano-4-(2-thienyl)-5,6,7,8-tetrahydroquinolin-2-ylsulfanyl]-N-phenyl-3-methylbutyramide (1a and 1b) were prepared from 2-thiophenaldehyde and D- and L-valines, respectively, and their crystal structures were elucidated by X-ray crystallography.
CalhounW., CarlsonR. P., CrossleyR., DatkoL. J., DietrichS., HeatheringtonK., MarshallL. A., MeadeP. J., OpalkoA., and ShepherdR. G., J. Med. Chem., 1995, 38, 1473.
2.
BeattieD.E., CrossleyR., CurranA. C., HillD. G., and LawrenceA. E., J. Med. Chem., 1977, 20, 718.
3.
WillemsM.I., DuboisG., BoydD. R., DaviesR. J., HamiltonL., McCulloughJ. J., and van BladerenP. J., Mutat. Res., 1992, 278, 227.
4.
ElgemeieG.H., ElfahhamH. A., and MekhamerR., Sulf. Lett., 1988, 8(4), 187.
5.
AndersonA., BelelliD., BennettD. J., BuchananK. I., CasulaA., CookeA., FeildenH., GemmellD. K., HamiltonN. M., HutchinsonE. J., LambertJ. J., MaidmentM. S., McGuireR., McPhailP., MillerS., MuntoniA., PetersJ. A., SansburyF. H., StevensonD., and SundaramH., J. Med. Chem., 2001, 44, 3582.
6.
IzumiyaN., and NagamatsuA., Bull. Chem. Soc. Jpn., 1952, 25, 2.
7.
BernardinelliG., and FlackH. D., Acta. Cryst., 1985, A41, 500.
8.
FlackH.G., and BernardinelliG., J. Appl. Cryst., 2000, 33, 1143.
9.
FlackH.G., Acta Cryst., 1983, A39, 876.
10.
ElgemeieG.E. H., HafezE. A. A., NawarG. A. M., and ElnagdiM. H., Heterocycles, 1984, 22, 2829.
11.
SheldrickG.M., Acta Cryst., 1990, A46, 467.
12.
DIRDIF94: BeurskensP.T., AdmiraalG., BeurskensG., BosmanW. P., Garcia-GrandaS., GouldR. O., SmitsJ. M. M., and SmykallaC., The DIRDIF-94 program system, Technical Report of the Crystallography Laboratory, University of Nijmegen, The Netherlands, 1994.
13.
CromerD.T., and WaberJ. T., International Tables for X-ray Crystallography, Kynoch Press, Birmingham, England, 1974, vol. 4, Table 2.2 A.
14.
IbersJ.A., and HamiltonW. C., Acta Cryst., 1964, 17, 781.
15.
CreaghD.C., and McAuleyW. J., International Tables for Crystallography, ed. WilsonA.J. C., Kluwer Academic Publishers, Boston, 1992, vol. C, Table 4.2.6.3.8, pp. 219–222.
16.
CreaghD.C., and HubbellJ. H., International Tables for Crystallography, ed. WilsonA.J. C., Kluwer Academic Publishers, Boston, 1992, vol. C, Table 4.2.4.3, pp. 200–206.
