An optically active β-hydroxyl–γ-butyrolactone was synthesised from nonchiral starting material by employing reductive cleavage reaction, Sharpless asymmetric epoxidation and dihydroxylation as key steps. This strategy can be used to prepare many chiral β-hydroxyl–γ-butyrolactone analogues. The crystal structure of 10 was determined by X-ray crystallographs.
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