Synthesis,Crystal and Biological Activity of 5-Chloro-3-(2,4-Dichlorophenyl)-N -(3-Methoxyphenyl)-2-Methyl-6-Phenylpyrazolo[1,5-A]Pyrimidin-7-Amine

Abstract

The crystal structure of 5-chloro-3-(2,4-dichlorophenyl)-N-(3-methoxyphenyl)-2-methyl-6-phenylpyrazolo[1,5-a]pyrimidin-7-amine (C₂₆H₁₉Cl₃N₄O, Mr = 509.80) has been synthesised by chlorination and aminisation from 3-(2,4-dichlorophenyl)-2-methyl-6-phenylpyrazolo[1,5-a]pyrimidine-5,7-diol. Its structure was confirmed by element analysis, IR, ¹H NMR and X-ray diffraction. The crystal belongs to the triclinic system, space group P-1 with a = 10.979(2) Å, b= 11.339(2) Å, c= 11.646(2) Å, a= 98.58(3) °, β= 110.21(3) °, γ= 111.61 (3) °. In addition, the compound possesses moderate anticancer activity.