Abstract
Synthesis of the 3,4-dehydropyroglutamate 5 has shown it to be unstable, forming the dimer 9 on chromatography and being too readily racemised to be considered as a useful chiral synthon.
Keywords
References
1.
Nàjera C.
, and
Yus M.
, Tetrahedron Asymmetry , 1999 , 10 , 2245 .
2.
see for example (a)
Herdeis C.
, and
Hubmann H. P
, Tetrahedron Asymmetry , 1992 , 3 , 1213 .
3.
Langlois N.
,
Calvez O.
, and
Radom M.-O.
, Tetrahedron Lett. , 1997 , 38 , 8037 .
4.
Dyer J.
,
Keeling S.
, and
Moloney M. G.
, J. Chem. Soc., Chem. Commun. , 1998 , 461 .
5.
Charrier J.-D.
,
Hadfield D. S.
,
Hitchcock P. B.
, and
Young D. W.
, Org. Biomol. Chem. , 2004 , 797 .
6.
August R.A.
,
Khan J. A.
,
Moody C. M.
, and
Young D. W.
, J. Chem. Soc., Perkin Trans. 1 , 1996 , 507 .