Abstract
Fentanyl, N-(1-phenethyl-4-piperidyl) propionanilide, was prepared by performing three successive one pot reactions at room temparature.
References
1.
Casy A.F.
, and
Parfitt R. T.
, Opioid Analgesics ; Plenum Press , New York , 1986 , p. 287 .
2.
Williams M.
,
Kowaluk E. A
, and
Arneric S. P.
, J. Med. Chem. , 1999 , 42 , 1481 .
3.
Micovic I.V.
,
Ivanovic M. D.
,
Vuckovic S. M.
,
Prostran M. S.
,
Dosen-Micovic Lj.
, and
Kiricojevic V. D.
, Bioorg. Med. Chem. Lett. , 2000 , 10 , 2011 .
4.
Micovic I.V.
,
Roglic G. M.
,
Ivanovic M. D.
,
Dosen-Micovic Lj.
,
Kiricojevic V. D.
, and
Popovic J. B.
, J. Chem. Soc., Perkin Trans., 1 , 1996 , 2041 .
5.
Janssen P.A. J.
, US Patent 3,164,600, 1965 .
6.The Merck Index , 12th edn. Merck., Inc. , NJ , 1996 .
7.
Janssen P.A. J.
,
Niemegeers C. J. E.
, and
Dony J. G. H.
, Arzeneim.-Forsch. (Drug Res.) , 1963 , 13 , 502 .
8.
Jeal W.
, and
Benfield P.
, Drugs , 1997 , 53 (1 ), 109 .
9.
Suh Y.-G.
,
Cho K.-H.
, and
Shin D.-Y.
, Arch. Pharmacol. Res. , 1998 , 21 (1 ), 70 .
10.
Zee S.-H.
,
Lai C.-L.
,
Wu Y.-U.
, and
Chen G.-S.
, K'Hsueh Fa Chan Yueh K'an , 1981 , 9 (5 ), 387 .
11.
Zee S.-H.
, and
Wang W.-K.
, J. Chin. Chem. Soc. , 1980 , 27 (4 ), 147 .
12.
Gribble G.W.
, and
Ferguson D. C.
, J. Chem. Soc., Chem. Commun. , 1975 , 535 .
13.
Evans D.A.
,
Chapman K. T.
, and
Carreira E. M.
, J. Am. Chem. Soc. , 1988 , 110 , 3560 .
14.
Abdel- Magid A.F.
,
Carson K. G.
,
Harris B. D.
,
Maryanoff C. A.
, and
Shah R. D.
, J. Org. Chem. , 1996 , 61 , 3849 .
