Efficient Synthesis of the Styryllactones,(+)-Goniothalamin,(+)-7- epi -Goniodiol and (+)-9-Deoxygoniopypyrone

Abstract

An efficient synthesis of (+)-goniothalamin is described with aldehyde 4 as the key intermediate; the absolute configuration of (+)-7-epi-goniodiol was determined through its asymmetric synthesis from (+)-goniothalamin and, based on the conformation analysis of the four dihydroxylated isomers of (+)-goniothalamin, it can be concluded that the absolute configuration of the hydroxy at C₈ determines the forms in nature.