A variety of polysubstituted thiophenes have been prepared via a solvent-free one-pot microwave assisted Gewald reaction using poly (ethylene glycol) as a soluble polymer support.
IversenL.F., AndersonH. S., BrannerS., MortensenS. B., PetersG. H., NorrisK., OlsenO. H., JeppesenC. B., LundtB. F., RipkaW., MollerK. B., and MollerN. P. H., J. Biol. Chem., 2000, 275, 10300.
2.
WebbT.R., MelmanN., Ji, LvovskiyX., and JacobsonK. A., Bioorg. Med. Chem. Lett., 2000, 10, 31.
3.
FujitaM., HirayamaT., and IkedaN., Bioorg. Med. Chem., 2002, 10, 3113.
4.
TjensH.L., ZickgrafA., FiglerH., LindenJ., OlssonR. A., ScammellsP. J., J. Med. Chem., 2003, 46, 1870.
5.
BaraldiP.G., RomagnoliR., PavaniM. G., NuñezM. C., TabriziM. A., ShryockJ. C., LeungE., MoormanA. R., UluogluC., IannottaV., MerighiS., and BoreaP. A., J. Med. Chem., 2003, 46, 794
6.
GewaldK., Angew. Chem., 1961, 73, 114
7.
SabnisR.W., RangnekarD. W., and SonawaneN. D.J. Heterocycl. Chem., 1999, 36, 333.
