Alkylation of Pyrrolidine-2,5-Dione with 2-(3,4-Dihydro-1-Naphthalenyl)Ethyl-4-Methylphenylsulfonates: A New and General Approach to 13-Aza-8,9-Dehydro-3-Desoxy-18-Norestrone Analogs
Free accessResearch articleFirst published online December, 2003
Alkylation of Pyrrolidine-2,5-Dione with 2-(3,4-Dihydro-1-Naphthalenyl)Ethyl-4-Methylphenylsulfonates: A New and General Approach to 13-Aza-8,9-Dehydro-3-Desoxy-18-Norestrone Analogs
Pyrrolidine-2,5-dione was N-alkylated with five different 2-(3,4-dihydro-1-naphthelenyl)ethyl-4-methylphenylsulfonates to afford the corresponding imides, which on reduction with NaBH4 in MeOH at −10°C followed by intramolecular cyclisation in POCl3 afforded the corresponding title compounds.
