Synthesis of [1,2,4]Triazolo[3,4-b]Pteridines as a Novel Class of Heterocyclic Compounds †

Abstract

A series of pteridine derivatives have been synthesised through intramolecular cyclisation of 2,4-dichloro-6-methyl-5-nitro pyrimidine with various esters of amino acids. The subsequently reaction of pteridines with hydrazine hydrate and then with triethylorthoesters obtained quantitatively the desired [1,2,4]triazolo[3,4-b]pteridine derivatives as a novel heterocyclic system.