The X-ray crystal structures of some 21-alkylpregnanes have been determined and the effects of a 16α,17α-epoxide and 21-methyl group on the conformation of the side chain are discussed.
For review see OjasooT., RaynardJ. P., and MornonJ. P. in Comprehensive Medicinal Chemistry Ed. HanschC., SammesP. G., and TaylorJ. B., Pergamon Press, Oxford, 1990, vol.3 chap.16.3 p.1200.
2.
DauxW.L., GriffinJ. F., and RohrerD. C., J. Am. Chem. Soc., 1981, 103, 6705.
3.
HazelJ.P, WeeksC. M., and OsawaY.Cryst. Struct. Commun., 1976, 5, 103.
4.
OsawaY., MakinoT., ShibataK., WeeksC. M., and DauxW. L., J. Chem. Soc. Chem. Commun.1976, 991.
5.
AndradeL.C. R., PaixaoJ. A., de AlmeidaM. J. M., MartinsR. M. L. M., SoaresH. I. M., MoraisG. J. R., MorenoM. J. S. M., Se e MeloM. L., and Campos-NevesA. S., Acta Cryst. Section C, 2001, C57, 537.
6.
WettsteinA., Helv. Chim. Acta, 1940, 23, 1371.
7.
GertosioV., SantiniC. C., BassetJ. M., BayardF., VivatM., and BuendiaJ., Eur. J. Org. Chem., 2000, 1521.
8.
HansonJ.R., KiranI., and ScarbroughC., J. Chem. Res., (S) in the press.
9.
HansonJ.R., and SalvadorJ., J. Chem. Res. (S) in the press.
10.
GuilloryJ.P., and BartellL. S., J. Chem. Phys., 1965, 43, 654.
11.
JohnsonF., Chem. Rev., 1968, 68, 375.
12.
CotterillW.D., and RobinsonM. J. T., Tetrahedron Lett., 1963, 1833.
