Granulosin, a chromone constituent of the bark of Galipea granulosa, and four analogues, all of which exhibit toxicity to the brine shrimp Artemia salina, have been prepared from 2′,3′,4′-trihydroxyacetophenone. High-resolution mass spectrometric analysis has permitted elucidation of the fragmentation patterns exhibited by these systems following electron-impact ionisation.
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The B/E link-scan data indicate that the direct fragmentations, M → VI (m/z 165), M → VII (m/z 164), and M–1 → VII (m/z 164), are typically favoured. In the case of granulosin 6c, how-ever, it is apparent that these are complemented by the fragmentations, IVc → VI (m/z 165), and IVc → VII (m/z 164).
