Functionalization of 1-methyl-1H-imidazole-5-carboxylic acid at the C-2 position: Efficient syntheses of 2-substituted t-butyl 1-methyl-1H-imidazole-5-carboxylates †

Abstract

A number of 2-substituted t-butyl 1-methyl-1H-imidazole-5-carboxylates, which can be readily converted to the corresponding acids, were efficiently prepared from t-butyl 2-bromo-1-methyl-1H-imidazole-5-carboxylate via brominelithium exchange or palladium-catalysed coupling.