2-Nitrobenzaldehydes (3a–c) on reaction with phosphoranes (4a and 4b), and triphenyl phosphine in refluxing diphenylether provide 2-acylindoles (6a–c) and 2-benzoylindoles (6d–f). Alternatively 2-nitrobenzaldeydes (3a–c) on reaction with phosphoranes (4a and 4b) give nitroketones (5a–f) which on refluxing with triphenyl phosphine in refluxing diphenyl ether furnish 2-acyl- and 2-benzoylindoles (6a–f).
References
1.
AelinoeP., MassiotG., and MenhourB., Nat. Prod. Lett., 1994, 15, 197.
2.
KatritzkyA.R., Comprehensive Heterocyclic Chemistry, Vol. 6, part 4B, Pergamon Press, Oxford, 1984, p. 61, and references cited therein.
