Fundamental understanding of life depends on both structural and functional details at the molecular level. Continually improving means of measurement of spatial and dynamic properties of biochemical constituents and cellular components complement studies of whole organisms. Integration of the interaction of components to provide coherent behaviour depends on highly elaborate orchestration in space and time. Whereas spatial information on a nanometre resolution is available, and fast dynamic analyses provide biochemical reaction rates measured in nanoseconds, functional coordination of the system requires integrated time dependence. While we are well aware of the special complexity of living organisms, appreciation of temporal scales and their organisation in time is still fragmentary. This article summarises current developments in research on biological time on scales from nanoseconds to years, the networks that connect different time domains and the oscillations, rhythms and biological clocks that coordinate and synchronise the complexity of the living state.
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