Abstract
This review discusses current development in biosensors for the detection of biological warfare agents (BWAs). BWAs include bacteria, virus and toxins that are added deliberately into air, water and food to spread terrorism and cause disease or death. The rapid and unambiguous detection and identification of BWAs with early warning signals for detecting possible biological attack is a major challenge for government agencies particularly military and health. The detection devices – biosensors – can be classified (according to their physicochemical transducers) into four types:. electrochemical, nucleic acid, optical and piezoelectric. Advantages and limitations of biosensors are discussed in this review followed by an assessment of the current state of development of different types of biosensors. The research and development in biosensors for biological warfare agent detection is of great interest for the public as well as for governments.
Keywords
References
1.
Allain C.C.
,
Poon L.S.
,
Chan C.G.W.
, and
Richmond P.C.F.
(1974 ) Clin. Chem. , 20 , 470 –475 .
2.
Witte D.L.
,
Barrett D.A.
, and
Wycoff D.A.
(1974 ) Clin. Chem. , 20 , 1282 –1286 .
3.
Karube I.
,
Hera K.
,
Matsuoka H.
, and
Suzuki S.
(1982 ) Anal. Chim. Acta , 139 , 127 –132 .
4.
Veldhoven V.
,
Meyhi P.P.
, and
Mannaerts G.P.
(1998 ) Anal. Biochem. , 258 , 152 –155 .
5.
Shahnaz B.
,
Tada S.
,
Kajikawa T.
,
Ishida T.
, and
Kawanishi K.
(1998 ) Ann. Clin. Biochem. , 345 , 665 –670 .
6.
Kennedy J.F.
(1975 ) In:
Wiseman A.
(ed.), Handbook of enzyme biotechnology , Chap. 4. John Wiley and Sons , New York .
7.
Tabata M.
,
Endo J.
, and
Murachi T.
(1981 ) J. Appl. Biochem. , 3 , 84 –92 .
8.
Pundir C.S.
, and
Suman
(2003 ) Curr. Appl. Phys. , 3 , 129 –133 .
9.
Braco L.
,
Daros J.A.
, and
Guardia M.
(1992 ) Anal. Chem. , 64 , 129 –133 .
10.
Singh S.
,
Solanki P.R.
, and
Malhotra B.D.
(2005 ) Anal. Chim. Acta , 568 , 126 –132 .
11.
Kennedy J.F.
(1985 ) In:
Weetall H.H.
(ed.), Handbook of enzyme technology , John Wiley and Sons , New York .
12.
Farrar W.E.
(1995 ) Pharos , 58 , 35 –38 .
13.
Walker H.D.
,
Yampolska O.
, and
Grinberg L.M.
(1994 ) Am. J. Pathol. , 144 , 1135 –1141 .
14.
John T.J.
(1996 ) Ind. J. Med. Res. , 103 , 4 –18 .
15.
Titball R.W.
,
Turnbull P.C.B.
, and
Hutson R.A.
(1991 ) J. Appl. Bacteriol. Symp. , 70 , 9s –18s .
16.
Lin H.J.
,
Charles P.T.
,
Andreadis J.D.
,
Churilla A.M.
,
Stenger D.A.
, and
Pancrazio J.J.
(2002 ) Anal. Chim. Acta , 457 , 97 –108 .
17.
Emanuel P.A.
,
Bell R.J.
,
Dang L.
,
McClanahan R.
,
David J.C.
,
Burgess R.J.
,
Thompson J.
,
Collins L.
, and
Hadfield T.
(2003 ) J. Clin. Microbiol. , 41 , 689 –693 .
18.
Liu W.
,
Montana V.
,
Chapman E.R.
,
Mohideen U.
, and
Parpura V.
(2003 ) Proc. Natl. Acad. Sci. USA , 100 , 13621 –13625 .
19.
Robinson-Dunn B.
(2002 ) Arch. Path. Lab. Med. , 126 , 291 –294 .
20.
Berman J.G.
, and
Henderson D.A.
(1998 ) N. Engl. J. Med. , 339 , 556 –559 .
21.
Steyn P.S.
(1995 ) Toxicol. Lett. , 82/83 , 843 –851 .
22.
Wannemacher R.W.
Jr.
, and
Wiener S.L.
(1997 ) In:
Sidell F.R.
,
Takafuji E.T.
, and
Franz D.R.
(eds), Medical aspects of chemical and biological warfare, office of the surgeon general , pp. 655 –676 . United States Army , VA .
23.
Lee W.E.
,
Thomson H.G.
,
Hall J.G.
,
Fulton R.E.
, and
Wong J.P.
(1993 ) Characteristics of the biochemical detector sensor , Defence Research Establishment Suffield, Canada. Suffield Memorandum No. 1402, 1 –23
24.
Ercole C.
,
Del Gallo M.
,
Pantalone M.
,
Santucci S.
,
Mosiello L.
,
Laconi C.
, and
Lepidi A.
(2002 ) Sens. Actuat. B , 4163 , 1 –5 .
25.
Ghindilis A.L.
,
Atanasov P.
,
Wilkins P.
, and
Wilkins E.
(1998 ) Biosens. Bioelectron. , 13 , 113 –131 .
26.
Mirhabibollahi B.
,
Brooks J.L.
, and
Kroll R.G.
(1990 ) Appl. Microbiol. Biotechnol. , 34 , 242 –247 .
27.
Brooks J.L.
,
Mirhabibollahi B.
, and
Kroll R.G.
(1990 ) Appl. Environ. Microbiol. , 56 , 3278 –3284 .
28.
Nakamura N.
,
Shigematsu A.
, and
Matsunaga T.
(1991 ) Biosens. Bioelectron. , 6 , 575 –580 .
29.
Brook J.L.
,
Mirhabibollahi B.
, and
Kroll R.G.
(1992 ) J. Appl. Bacteriology , 73 , 189 –196 .
30.
Kim H.J.
,
Bennetto H.P.
, and
Haqlablab M.A.
(1995 ) Biotechnol. Technol. , 9 , 389 –394 .
31.
Gau J.
,
Lan E.H.
,
Dunn B.
,
Ho C.
, and
Woo J.C.S.
(2001 ) Biosens. Bioelectron. , 16 , 745 –755 .
32.
Brewster J.D.
,
Gehring A.G.
,
Mazenko R.S.
,
Vanhouten L.J.
, and
Crawford C.J.
(1996 ) Anal. Chem. , 68 , 4153 –4159 .
33.
Gehring A.G.
,
Crawford C.G.
,
Mazenko R.S.
,
Van Houten L.J.
, and
Brewster J.D.
(1996 ) J. Immunol. Meth. , 195 , 15 –25 .
34.
Perez F.G.
,
Mascini M.
,
Tothill I.E.
, and
Turner A.P.F.
(1998 ) Anal. Chem. , 70 , 2380 –2386 .
35.
Brewster J.D.
, and
Mazenko R.S.
(1998 ) J. Immunol. Meth. , 211 , 1 –8 .
36.
Che Y.
,
Li Y.
, and
Slavik M.
(2001 ) Biosens. Bioelectron. , 16 , 791 –797 .
37.
Yao T.
,
Sato M.
,
Kobayashi Y.
, and
Wasa T.
(1985 ) Anal. Biochem. , 149 , 387 –391 .
38.
Moody G.J.
,
Sanghera G.S.
, and
Thomas J.D.R.
(1988 ) Analyst , 113 , 1419 –1423 .
39.
Wolfgang T.
,
Lionti I.
,
Marco
, and
Mascini
, (1993 ) Electroanalysis , 5 , 753 –763 .
40.
Gilmartin M.A.T.
, and
Hart J.P.
(1994 ) Analyst , 119 , 2331 –2336 .
41.
Solanki P.R.
,
Arya S.K.
,
Nishimura Y.
,
Iwamoto M.
, and
Malhotra B.D.
(2007 ) Langmuir , 23 , 7398 –7403 .
42.
Charpentier L.
, and
Murr N.
(1995 ) Anal. Chim. Acta , 318 , 89 –93 .
43.
Sean B.
,
Dyer N.S.
, and
Anthony G.
(2001 ) Anal. Chim. Acta , 448 , 27 –36 .
44.
Nuria P.
,
Gloria Ruiz
,
Julio
,
Reviejo A.
,
Jose M.
, and
Pingarron
(2001 ) Anal. Chem. , 5 , 1190 –1195 .
45.
Vidal J.C.
,
Garcia E.
, and
Castillo J.R.
(2002 ) Anal. Sci. , 18 , 537 –542 .
46.
Vidal J.C.
,
Espuelas J.
,
Garica-Ruiz E.
, and
Castillo J.R.
(2004 ) Talanta , 64 , 655 –664 .
47.
Vidal J.C.
,
Espuelas J.
, and
Castillo J.R.
(2004 ) Anal. Biochem. , 333 , 88 –98 .
48.
Jianping L.
, and
Peng Y.
(2003 ) Electroanalysis , 15 , 1031 –1033 .
49.
Endo H.
,
Masashi M.
,
Mio T.
,
Huifeng R.
,
Tetushito H.
,
Naoto U.
, and
Kohji M.
(2003 ) Science , 106 , 1194 –1199 .
50.
Singh S.
,
Chaubey A.
, and
Malhotra B.D.
(2004 ) Anal. Chim. Acta , 502 , 229 –234 .
51.
Tan X.
,
Li M.
,
Cai P.
,
Luo L.
, and
Zou X.
(2004 ) Anal. Biochem. , 337 , 111 –120 .
52.
Simonian A.L.
,
Good T.A.
,
Wang S.S.
,
Wild J.R.
(2005 ) Anal. Chim. Acta , 534 , 69 –77 .
53.
Song M.J.
,
Yun D.H.
,
Jin J.H.
,
Min N.K.
, and
In Hong S.
(2006 ) Jpn. J. Appl. Phys. , 45 , 7197 –7202 .
54.
Vikas
, and
Pundir C.S.
(2008 ) J. Sci. Ind. Res. , 67 , 299 –306 .
55.
Adhikari B.
, and
Majumdar S.
(2004 ) Prog. Polym. Sci. , 29 , 699 –766 .
56.
Oesch U.
,
Ammann D.
, and
Simon W.
(1986 ) Clin. Chem. , 32 , 1448 –1459 .
57.
Benco J.S.
,
Nienaber H.A.
, and
McGimpsey W.G.
(2003 ) Anal. Chem. , 75 , 152 –156 .
58.
Rucka M.
, and
Turkiewicz B.
(1989 ) Appl. Biochem. Biotechnol. , 22 , 119 –127 .
59.
Shaw J.F.
,
Chang R.C.
,
Wang F.F.
, and
Wang Y.J.
(1989 ) Biotechnol. Bioeng. , 35 , 132 –137 .
60.
Karakus E.
,
Pekyardimci S.
, and
Esma K.
(2005 ) Immobil. Biotechnol. , 33 , 329 –341 .
61.
Tinkilic N.
,
Cubuk O.
, and
Isildak I.
(2002 ) Anal. Chim. Acta , 452 , 29 –34 .
62.
Goldstein G.
(1976 ) J. Chromatogr. , 129 , 61 –72 .
63.
Guibault G.G.
(1984 ) In:
Dekker M.
(ed.), Analytical uses of immobilised enzymes , Wiley , New York .
64.
Sukeerthi S.
, and
Contractor A.Q.
(1994 ) Ind. J. Chem. , 33A , 565 –571 .
65.
Gerard M.
,
Chaubey A.
, and
Malhotra B.D.
(2002 ) Biosens. Bioelectron. , 17 , 345 –359 .
66.
Cullen D.C.
,
Sethi R.S.
, and
Lowe C.R.
(1990 ) Anal. Chim. Acta , 231 , 33 –40 .
67.
Silley P.
, and
Forsythe S.
(1996 ) J. Appl. Bacteriol. , 80 , 233 –243 .
68.
Milner K.R.
,
Brown A.P.
,
Allsopp D.W.E.
, and
Betts W.B.
(1998 ) Electron. Lett. , 34 , 66 –68 .
69.
Desilva M.S.
,
Zhang Y.
,
Hesketh P.J.
,
Maclay G.J.
,
Gendel S.M.
, and
Steller J.R.
(1995 ) Biosens. Bioelectron. , 10 , 669 –682 .
70.
Sergeyeva T.A.
,
Lavrik N.V.
,
Rachkov A.E.
,
Kazantseva Z.I.
, and
EI Skaya A.V.
(1998 ) Biosens. Bioelectron. , 13 , 359 –369 .
71.
Ehret R.
,
Baumann W.
,
Brischwein M.
,
Schwinde A.
,
Stegbauer K.
, and
Wolf B.
(1997 ) Biosens. Bioelectron. , 12 , 29 –41 .
72.
Pless P.
,
Futschik K.
, and
Schopf E.
(1994 ) J. Food Protect. , 57 , 369 –376 .
73.
Higgins J.A.
,
Ibrahim M.S.
,
Knauert F.K.
,
Ludwig G.V.
,
Kijek T.M.
,
Ezzell J.W.
,
Courtney B.C.
, and
Henchal E.A.
(1994 ) Ann. N. Y. Acad. Sci. , 894 , 130 –148 .
74.
Hartley H.A.
, and
Baeumner A.J.
(2003 ) Anal. Bioanal. Chem. , 376 , 319 –327 .
75.
Versage J.L.
,
Severin D.D.M.
,
Chu M.C.
, and
Petersen J.M.
(2003 ) J. Clin. Microbiol. , 41 , 5492 –5499 .
76.
Ibrahim M.S.
,
Lofts R.S.
,
Jahrling P.B.
,
Henchal E.A.
,
Weedn V.W.
,
Northrup M.A.
, and
Belgrader P.
(1998 ) Anal. Chem. , 70 , 2013 –2017 .
77.
Belgrader P.
,
Elkin C.J.
,
Brown S.B.
,
Nasarabadi S.N.
,
Langlois R.G.
,
Milanovich F.P.
,
Colston B.W.
, and
Marshall G.D.
(2003 ) Anal. Chem. , 75 , 3446 –3450 .
78.
Emanuel P.A.
,
Bell R.
,
Dang J.L.
,
McClanahan R.
,
David J.C.
,
Burgess R.J.
,
Thompson J.
,
Collins L.
, and
Hadfield T.
(2003 ) J. Clin. Microbiol. , 41 , 689 –693 .
79.
Panning M.
,
Asper M.
,
Kramme S.
,
Schmitz H.
, and
Drosten C.
(2004 ) Clin. Chem. , 50 , 702 –708 .
80.
Laassri M.
,
Chizhikov V.
,
Mikheev M.
,
Shchelkunov S.
, and
Chumakov K.
(2003 ) J. Virol. Meth. , 112 , 67 –78 .
81.
Higgins J.A.
,
Nasarabadi S.
,
Karns J.S.
,
Shelton D.R.
,
Cooper M.
,
Gbakima A.
, and
Koopman R.P.
(2003 ) Biosens. Bioelectron. , 18 , 1115 –1123 .
82.
Lin H.J.
,
Charles P.T.
,
Andreadis J.D.
,
Churilla A.M.
,
Stenger D.A.
, and
Pancrazio J.J.
(2002 ) Anal. Chim. Acta , 457 , 97 –108 .
83.
Baeumner A.J.
,
Leonard B.
,
McElwee J.
, and
Montagna R.A.
(2004 ) Anal. Bioanal. Chem. , 380 , 15 –23 .
84.
Glazier S.A.
, and
Weetall H.H.
(1994 ) J. Microbiol. Meth. , 20 , 23 –27 .
85.
Tims T.B.
, and
Lim D.V.
(2004 ) J. Microbiol. Meth. , 59 , 127 –30 .
86.
Bringham-Burke M.
,
Edwards J.R.
, and
O'Shannessy D.J.
(1992 ) J. Anal. Biochem. , 205 , 125 –131 .
87.
Hsieh H.V.
,
Stewart B.
,
Hauer P.
,
Haaland P.
, and
Campbell R.
(1998 ) Vaccine , 16 , 997 –1003 .
88.
Oh B.K.
,
Lee W.
,
Chun B.S.
,
Bae Y.M.
,
Lee W.H.
, and
Choi J.W.
(2005 ) Biosens. Bioelectron. , 20 , 1847 –1850 .
89.
Watts H.J.
,
Lowe C.R.
, and
Pollard-Knight D.V.
(1994 ) Anal. Chem. , 66 , 2465 –2470 .
90.
Schneider B.H.
,
Edwards J.G.
, and
Hartman N.F.
(1997 ) Clin. Chem. , 43 , 1757 –1763 .
91.
Cao K.L.
,
Anderson G.P.
,
Ligler F.S.
, and
Ezzel J.
(1995 ) J. Clin. Microbiol. , 33 , 336 –341 .
92.
Wijesuriya D.C.
,
Anderson G.P.
, and
Ligler F.S.
(1994 ), In:
Berg D.A.
, and
Williams J.D.
,
Reeves J.
, and
Reeves P.J.
(eds), Proc. 1993 ERDEC Scientific Conference on Chemical Defence Research , pp. 671 –677 . Report No. ERDEC-SP-024 16–19 November 1993, Maryland.
93.
Carlson M.A.
,
Bargeron C.B.
,
Benson R.C.
,
Fraser A.B.
,
Phillips T.E.
,
Velky J.T.
,
Groopman J.D.
,
Strickland P.T.
, and
Ko H.W.
(2000 ) Biosens. Bioelectron. , 14 , 841 –848 .
94.
Kwakye S.
, and
Baumner A.
(2003 ) Anal. Bioanal. Chem. , 376 , 1062 –1068 .
95.
Koch S.
,
Wolf H.
,
Danapel C.
, and
Feller K.A.
(2000 ) Biosens. Bioelectron. , 14 , 779 –784 .
96.
Prusak-Sochaczewski E.
,
Luong J.H.T.
, and
Guilbault G.G.
(1990 ) Enzyme Microbiol. Technol. , 12 , 173 –177 .
97.
Plomer M.
,
Guilbault G.G.
, and
Hock B.
(1992 ) Enzyme Microb. Technol. , 14 , 230 –235 .
98.
Carter R.M.
,
Mekalanos J.J.
,
Jacobs M.B.
,
Lubrano G.J.
, and
Guilbault G.G.
(1995 ) J. Immunol. Meth. , 187 , 121 –125 .
99.
Wong Y.Y.
,
Ng S.P.
,
Ng M.H.
,
Si S.H.
,
Yao S.Z.
, and
Fung Y.S.
(2002 ) Biosens. Bioelectron. , 17 , 676 –84 .
100.
Zuo B.
,
Li S.
,
Guo Z.
,
Zhang J.
, and
Chen C.
(2004 ) Anal. Chem. , 76 , 3536 –3540 .
101.
Pohanka M.
, and
Skládal P.
(2005 ) Analyt. Lett. , 38 , 411 –422 .
102.
Edelstein R.L.
,
Tamanaha C.R.
,
Sheehan P.E.
,
Miller M.M.
,
Baselt D.R.
,
Whitman L.J.
, and
Colton R.J.
(2000 ) Biosens. Bioelectron. , 14 , 805 –813 .
103.
Viveros L.
,
Paliwal S.
,
McCrae D.
,
Wild J.
, and
Simonian A.
(2006 ) Sensors Actuators B: Chem. , 115 (1 ).
104.
Nicolos J.L.
(2010 ) Improving the stability of an oxime based electrochemical microsensor for organophosphate vapor detection , PhD thesis, Graduate College of the University of Illinois at Urbana-Champaign (2010).
105.
Balasubramanian S.G.S.
(2006 ) Sens. Actuat. B-Chem. , 115 , 150 –157 .
106.
Gooding J.J.
(2006 ) Analyt. Chim. Acta , 559 , 137 –151 .