Abstract
The field of microfluidics, often also referred to as “Lab-on-a-Chip” has made significant progress in the last 15 years and is an essential tool in the development of new products and protocols in the life sciences. This article provides a broad overview on the developments on the academic as well as the commercial side. Fabrication technologies for polymer-based devices are presented and a strategy for the development of complex integrated devices is discussed, together with an example on the use of these devices in pathogen detection.
Keywords
References
1.
Manz A.
,
Graber N.
, and
Widmer M.
(1990 ) Sens Actuators , B1 , 244 –248 .
2.
Becker H.
, and
Manz A.
(1996 ) Sci. Prog. , 79 (1 ), 49 –63 .
3.Search in the PubMed database (http://www.ncbi.nlm.nih.gov/pubmed), conducted 15.5.2011. Search term: (microfluidic[Title/Abstract]) AND “YEAR”[Entrez Date]: “YEAR”[Entrez Date]
4.
Blow N.
(2009 ) Nature Meth. , 6 , 683 –686 .
5.
Fenn F.
, and
Raskino M.
(2008 ) Mastering the hype cycle- how to choose the right innovation at the right time , Harvard Business Press , Cambridge .
6.
Terry S.C.
,
Jermann J.H.
, and
Angell J.B.
(1979 ) IEEE Trans. Electron. Devices , ED-26 , 1880 –1886 .
7.
Hardt S.
;
Schönfeld F.
(2010 ) Microfluidic technologies for miniaturised analysis system , Springer , Berlin .
8.
Tabeling P.
(2006 ) Introduction to microfluidics , Oxford University Press .
9.
Herold K:E.
, and
Rasooly A.
(eds) (2009 ) Lab-on-a-Chip Technology, Vol. 1, Fabrication and microfluidics , Caister Academic Press , Hethersett .
10.
Becker H.
, and
Gärtner C.
(2008 ) Anal. Bioanal. Chem. 390 , 89 –111 .
11.
Sia S.K.
, and
Whitesides G.M.
(2003 ) Electrophoresis. 24 , 3563 –3576 .
12.
Kartalov E.P.
,
Anderson W.F.
, and
Scherer A.
(2006 ) J. Nanosci. Nanotechnol. , 6 (8 ), 2265 –2277 .
13.
Melin J
, and
Quake S.R.
(2007 ) Annu. Rev. Biophys. Biomol. Struct. , 36 , 213 –231 .
14.
Pu Q.S.
,
Luttge R.
,
Gardeniers J.G.E.
, and
van den Berg A.
(2003 ) Electrophoresis. , 24 , 162 –171 .
15.
Becker H.
,
Arundell M.
,
Harnisch A.
, and
Hülsenberg D.
(2002 ) Sens. Actuators B. , 86 , 271 –279 .
16.
Osellame R.
,
Hoekstra H.J.W.M.
,
Cerullo G.
, and
Pollnau M.
(2011 ) Laser Photon. Rev. , 5 (3 ), 442 –463 .
17.
Khan Malek C.
, and
Saile V.
(2004 ) Microelectronics J. , 35 , 131 –143 .
18.
Edwards T.L.
,
Mohanty S.K.
,
Edwards R.K.
,
Thomas C.L.
, and
Frazier B.A.
(2002 ) Sensors Mater. , 14 , 167 –78 .
19.
McCormick R.M.
,
Nelson R.J.
,
Alonso-Amigo M.G.
,
Benvegnu D.J.
, and
Hooper H.H.
(1997 ) Anal. Chem. , 69 , 2626 –2630 .
20.
Mair D.A.
,
Geiger E.
,
Pisano A.P.
,
Frechet J.M.
, and
Svec F.
(2006 ) Lab Chip , 6 , 1346 –1354 .
21.
Becker H.
(2009 ) Lab Chip , 9 , 2759 –2762 .
22.
Liu C. C.
, and
Cui D. F.
(2005 ) Microsystem Technol. , 11 , 1262 –1266 .
23.
Brischwein M.
2006 ) Lab Chip , 6 , 819 –822 .
24.
van Osch T.H.J.
,
Perelaer J.
,
de Laat A.W.M.
, and
Schubert U.S.
(2008 ) Adv. Mater. , 20 , 343 –345 .
25.
Soper S.A
,
Henry A.C.
,
Vaidya B.
,
Galloway M.
,
Wabuyele M
, and
McCarley R.L.
(2002 ) Anal. Chim. Acta , 470 , 87 –99 .
26.
Locascio L.E.
,
Henry A.C.
,
Johnson T.J.
, and
Ross D.
(2003 ) In:
Oosterbroeck R.E.
, and
van den Berg A.
(eds), Lab-on-a-Chip , Elsevier 65 –82 .
27.
Belder D.
, and
Ludwig M.
(2003 ) Electrophoresis , 24 , 3595 –3606 .
28.
Erickson D.
(2005 ) Microfluid. Nanofluid. , 1 , 301 –318 .
29.
Schulte T.
,
Bardell R.
, and
Weigl B.H.
(2000 ) JALA , 5 (4 ), 83 –86 .
30.
Kim J.
,
Johnson M.
,
Hill P.
, and
Gale B.K.
(2009 ) Integr. Biol. , 1 , 574 –586 .
31.
Zhang C.
,
Xu J.
,
Ma W.
, and
Zheng W.
(2006 ) Biotechnol. Adv. , 24 , 243 –284 .
32.
Asiello P.J.
, and
Baeumner A.J.
(2011 ) Lab Chip , 11 (8 ), 1420 –1430 .
33.
Konry T.
,
Smolina I.
,
Yarmush J.M.
,
Irimia D.
, and
Yarmush M.L.
(2011 ) Small , 7 (3 ), 395 –400 .
34.
Lenigk R.
2002 ) Anal. Biochem. , 311 , 40 –49 .
35.
Kuswandi B.
,
Nuriman
,
Huskens J.
, and
Verboom W.
(2007 ) Anal. Chim. Acta , 601 , 141 –155 .
36.
Vandaveer W.R.
,
Pasas-Farmer S.A.
,
Fischer D.J.
,
Frankenfeld C.N.
, and
Lunte S.M.
(2004 ) Electrophoresis , 25 , 3528 –3549 .
37.
Fu Y.Q.
,
Luo J.K.
,
Du X.Y.
,
Flewitt A.J.
,
Li Y.
,
Markx G.H.
,
Walton A.J.
, and
Milne W.I.
(2010 ) Sens. Actuators B , 143 , 606 –619 .
38.
Sagmeister B.P.
,
Graz I.M.
,
Schwödiauer R.
,
Gruber H.
, and
Bauer S.
(2009 ) Biosensors Bioelectronics , 24 , 2643 –2648 .
39.
Kopp M.U.
,
De Mello A.J.
, and
Manz A.
(1998 ) Science , 280 , 1046 –1048 .
40.
Schneegaß I.
, and
Köhler J.M.
(2001 ) Rev. Mol Biotechnol. , 82 , 101 –121 .
41.
Bruin G.J.M.
(2000 ) Electrophoresis , 21 , 3931 –3951 .
42.
Hessel V.
,
Renken A.
,
Schouten J.C.
, and
Yoshida J.
(eds) (2009 ) Micro process engineering: a comprehensive handbook , Wiley-VCH .
43.
Andersson H.
, and
van den Berg A.
(eds) (2004 ) Lab-on-Chips for cellomics , Kluwer , New York .
44.
El-Ali J.
,
Sorger P.K.
, and
Jensen K.F.
(2006 ) Nature , 442 , 403 –411 .
45.
Paguirigan A.L.
, and
Beebe D.J.
(2008 ) BioEssays , 30 , 811 –821 .
46.
Schütte J.
2011 ) Biomed. Microdev. , 13 (3 ), 493 –501 .
47.
Carstens C.
,
Elbracht R.
,
Gärtner C.
, and
Becker H.
(2010 ) Expert Opin. Drug Discov. , 5 , 673 –679 .
48.
Ducrée J.
,
Zengerle R.
, and
Newman J.
(2004 ) FlowMap: microfluidics roadmap for the life sciences , Books on Demand .
49.Yole Developpement (2009 ) Emerging markets for microfluidics applications.
50.
Melanson S.E.F.
(2011 ) Point of Care , 10 , 63 –68 .
51.
Fragoso A.
,
Latta D.
2011 ) Lab Chip , 11 , 625 –631 .
52.
Meltzer R.H.
2011 ) Lab Chip , 11 , 863 –873 .
53.
http://biopharmguy.com/diagnostics.php, accessed 20.02.2012.
54.
Becker H.
(2010 ) Lab Chip , 10 , 1894 –1897 .
55.
Yager P.
,
Edwards T.
,
Fu E.
,
Helton K.
,
Nelson K.
,
Tam M.R.
, and
Weigl B.H.
(2006 ) Nature , 442 , 412 –418 .
56.
http://www.xprise.org/prise-development/life-sciences#artificial, accessed 19.7.2011.