Abstract
Summary
Sex differences in control blood values of box turtles are presented. Mild to toxic doses of cobalt, including mineral supplement and injections of crude liver extract failed to stimulate erythropoiesis. Marked reticulocytosis was induced by repeated bleeding. High reticulocyte counts persisted for 3 weeks following the last bleeding and 4 months were required for restoration of normal erythrocyte values. Blood formation was altered by injections of folic acid antagonist, aminopterin. Arrested maturation of blood cells was detected in form of enlarged marrow blast cells as early as 5 weeks and anemia and leucopenia followed after 6 weeks treatment.
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