Abstract
Summary
Additional evidence is presented for the existence of a new factor essential for utilization of mevalonic acid. This factor is present in autoclaved extracts of fresh liver from several species but absent from auto-lyzed liver. It is heat stable but is lost on dialysis or exposure to pH 0.5 and to a lesser extent by exposure to pH 11.0. A variety of biological compounds has been examined for activity. No compound thus far studied, including coenzyme A, will replace natural material.
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