Abstract
Summary
A small proportion of mice inoculated with cortisone alone died or developed ascites and/or liver lesions. Bacteria were isolated from some of the livers showing cortisone-induced lesions. Homogenates of such livers were not infective for normal suckling Swiss mice. Cortisone acetate reduced susceptibility of normally resistant weanling Swiss mice to infection with the Gledhill strain of mouse hepatitis virus. The effectiveness of cortisone in decreasing host resistance was enhanced as dosage of the steroid was increased. There was a decrease in this cortisone effect as the time interval between virus and cortisone administration was increased from 1 to 5 days.
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